pntd.0005389.g004.tif (195.32 kB)
Difference in Ct values at Day-2 (left) or Day-4 (right) from baseline (the larger the value the larger the viral decline) versus drug concentrations.
figure
posted on 2017-02-23, 18:59 authored by Thi Huyen Tram Nguyen, Jérémie Guedj, Xavier Anglaret, Cédric Laouénan, Vincent Madelain, Anne-Marie Taburet, Sylvain Baize, Daouda Sissoko, Boris Pastorino, Anne Rodallec, Géraldine Piorkowski, Sara Carazo, Mamoudou N. Conde, Jean-Luc Gala, Joseph Akoi Bore, Caroline Carbonnelle, Frédéric Jacquot, Hervé Raoul, Denis Malvy, Xavier de Lamballerie, France MentréTop: patients with a low baseline Ct value (Ct<20) (n = 15 and 12); bottom: patients with a high baseline Ct value (Ct>=20) (bottom, n = 26 and 37). Red points represent concentrations measured in patients who died during the trial, green points represent concentrations measured in those who survived. Triangles indicate Ct values that were above 40 (detection limit) and were treated as equal to 40, and circles are observed values. Black lines are Loess trend lines.
