pr800990x_si_003.tif (1.68 MB)
Developmental Brain Protein Level Changes in the C57BL/6J Mouse
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posted on 2009-03-06, 00:00 authored by Jae-Kyung Myung, Ki Shuk Shim, Lin Li, Harald Höger, Gert LubecAs work on systematic searches for developmentally-regulated proteins is limited, whole brains of CL57B/6J mice were taken from day 16 of gestation, at postnatal days 7 and 54−58. Proteins were extracted, and analyzed by a gel-based proteomic method (ion trap HCT). Antioxidant, cytoskeleton, chaperone, several metabolic proteins from different pathways, proteins from the protein synthetic and degradation machinery, sirtuin and a mitochondrial inner membrane protein were developmentally regulated.