Details of the two final models of the NTpolyQ_TPR1-3 fragment.

(A) The final models (Top: model-1; Bottom: model-2) in cartoon representation. The N11, Qx16 and TPR regions are colored in cyan, yellow and green, respectively. The TPR domain is also depicted as a surface colored according to (B) electrostatic potentials and (C) Ssn6 mutational data; in red/orange: point mutation sites disrupting/affecting Tup1 interaction [20, 26]. Hydrophobic Ssn6 residues are labeled in B. (D) Cartoon representation of the models with details of the mutations colored in C.