ppat.1007428.g006.tif (1.46 MB)
Delayed oseltamivir plus sirolimus treatment decreased the levels of various proinflammatory cytokines and chemokines in the BALF.
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posted on 2018-11-13, 18:31 authored by Xuehong Jia, Bo Liu, Linlin Bao, Qi Lv, Fengdi Li, Hui Li, Yunqing An, Xulong Zhang, Bin Cao, Chen WangThe concentrations of eotaxin, IFN-γ, IL-1α, IL-10, KC, MCP-1, MIP-1β, RANTES, TNF-α, G-CSF, GM-CSF, IL-6, IL-12 (p40), IL-12 (p70), IL-17 and MIP-1α in the BALF of infected mice in different treatment groups at 7 dpi. Data are representative of two independent experiments and presented as mean ± SEM (n = 5 for each group). *, **, and *** represent p < 0.05, 0.01, and 0.001, respectively.
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influenzapH 1N infection mice modelH 1N pdm 09 viruslung injuryNOD-like receptor family pyrin domainsirolimus treatment attenuates H 1N virus-inducedpH 1N mTOR activationbronchioalveolar lavage fluidNLRP 3 inflammasome activationH 1N infectionlung epithelial cell linereactive oxygen species productionmTOR-NLRP 3-IL axisNFcell infiltrationimmunopathological lung injuryvirus infection causesoseltamivir attenuates pH 1NpH 1N infection
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