Supplementary Table 1.xlsx (101.97 kB)
Dataset for: Rapid proteomic analysis for solid tumors reveals LSD1 as a drug target in an end stage cancer patient
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posted on 2018-08-07, 06:29 authored by Sophia Doll, Maximilian C Kriegmair, Alberto Santos Delgado, Fabian Coscia, Helen Michele Neil, Michael Wierer, Stefan Porubsky, Philipp E Geyer, Andreas Mund, Philipp Nuhn, Matthias MannRecent advances in mass spectrometry (MS)-based technologies are now set to transform translational cancer proteomics from an idea to a practice. Here, we present a robust proteomic workflow for the analysis of clinically relevant human cancer tissues that allows quantitation of thousands of tumor proteins in several hours of measuring time and a total turnaround of a few days. We applied it to a chemorefractory metastatic case of the extremely rare urachal carcinoma. Quantitative comparison of lung metastases and surrounding tissue revealed several significantly upregulated proteins, among them lysine specific histone demethylase 1 (LSD1/KDM1A). LSD1 is an epigenetic regulator and the target of active development efforts in oncology. Thus clinical cancer proteomics can rapidly and efficiently identify actionable therapeutic options. While currently described for a single case study, we envision that it can be applied broadly to other patients in a similar condition.
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- Oncology and carcinogenesis not elsewhere classified
- Tumour immunology
- Medical biochemistry and metabolomics not elsewhere classified
- Proteomics and intermolecular interactions (excl. medical proteomics)
- Plant cell and molecular biology
- Animal cell and molecular biology
- Clinical pharmacology and therapeutics
- Genomics
- Cancer cell biology
- Cancer genetics
- Chemotherapy
Keywords
case studyclinical proteomicsepigeneticsmass spectrometryurachal carcinomaCancerTumour ImmunologyMedical Biochemistry and Metabolomics not elsewhere classifiedProteomics and Intermolecular Interactions (excl. Medical Proteomics)Molecular BiologyClinical Pharmacology and TherapeuticsBiomarkersGenomicsCancer Cell BiologyCancer GeneticsChemotherapy
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