Database of Global Research Activity on Manganese (DOGRAM)

2016-12-07T11:37:18Z (GMT) by Institute of Environment and Health
In 2016, the MHRP database/website was closed, and this fileset is the csv export of database content (one csv for each table; tblIAddress is indeed empty), preserved as it may still be of value to researchers in this area. The MHRP project description follows:<br><br>In addition to the research being conducted as part of the MHRP, there are many other activities underway world-wide. In order to provide interested stakeholders with up to date information on the scope of global research in progress, and to identify the scientists currently active in relevant fields, the Institute of Environment and Health (IEH) has developed this web-based database of research activities (DOGRAM), as part of its contribution in support of the MHRP.<br><br><b>What is DOGRAM</b><br>DOGRAM is a fully searchable inventory of current research activities relating to the potential health effects of, and methods of controlling and treating, exposure to Mn. As such, its scope is intended to encompass investigation of both inorganic and organic forms of Mn, and includes:<br><br>- Estimation of the contributions of environmental and occupational Mn exposure to health, disease and dysfunction;<br>- Investigation of the physiological and biochemical mechanisms (including toxicokinetic considerations);<br>- Investigation of the physiological mechanisms that govern manganese accumulation within the brain, with special emphasis on the role of olfactory transport of the metal;<br>- Assessment of the influence of factors, such as age, nutritional deficiencies, pre-existing disease and genetics, that influence individual susceptibility to Mn;<br>- Investigation of the roles and mechanisms of Mn toxicity, including its role in neurodegenerative disease;<br>- Measurement and/or modelling of occupational or environmental exposure;<br>- Identification of existing and novel biomarkers of exposure or adverse effects; and<br>- Development and implementation of new medical approaches to the treatment of excessive Mn exposure.<br><br>DOGRAM will thus provide an effective and powerful tool for identifying current, and recently completed, research activities and the key workers in relevant fields. As such, it should be of value to stakeholders and researchers, providing a means of minimizing the risk of duplication of effort, and over time should facilitate the identification of changing patterns of research activity, gaps in programmes, opportunities for collaboration, and emerging areas of concern.