Daryamide Analogues from a Marine-Derived <i>Streptomyces</i> species

2017-02-22T14:05:53Z (GMT) by Peng Fu Scott La John B. MacMillan
Three new cyclohexene amine derivatives, daryamides D–F (<b>1</b>–<b>3</b>), a new arylamine derivative, carpatamide D (<b>4</b>), and a new ornithine lactamization derivative, ornilactam A (<b>5</b>), were isolated from the marine-derived <i>Streptomyces</i> strain SNE-011. Their structures, including absolute configurations, were elucidated on the basis of spectroscopic analysis and chemical methods. The carpatamide skeleton could be considered as the biosynthetic precursor of the daryamides.