np200755t_si_001.pdf (7.92 MB)
Cyclopeptide Alkaloids from Ziziphus apetala
journal contribution
posted on 2011-12-27, 00:00 authored by Jing Han, Chang-Jiu Ji, Wen-Jun He, Yu Shen, Ying Leng, Wen-Yan Xu, Jun-Ting Fan, Guang-Zhi Zeng, Ling-Dong Kong, Ning-Hua TanSix novel Ia3-type cyclopeptide alkaloids
(1–6) were isolated from stems of Ziziphus
apetala. Compound 5 and the known compounds
mauritine A (7) and mauritine F (8) were
isolated from the roots. Their structures were determined by spectroscopic
analyses and chemical methods. The total alkaloids from the roots
and the isolated cyclopeptide alkaloids were tested for antidepressant
behavior on mice, cytotoxicity, and 11β-hydroxysteroid dehydrogenase
(11β-HSD) inhibition in vitro. Only mauritine A (7) showed inhibitory activity on 11β-HSD1, with IC50 values of 52.0 (human) and 31.2 μg/mL (mouse).