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Curcumin Eutectics with Enhanced Dissolution Rates: Binary Phase Diagrams, Characterization, and Dissolution Studies
journal contribution
posted on 2018-09-21, 18:18 authored by Indumathi Sathisaran, Jenna Marie Skieneh, Sohrab Rohani, Sameer Vishvanath DalviCurcumin is a potentially viable
pharmaceutical ingredient obtained
from the rhizome of a turmeric plant, Curcuma longa. It is a polyphenolic compound which is known to possess antibacterial,
anti-inflammatory, antitumor, and anticancer properties. Its use in
pharmaceutical applications has been limited because of its poor aqueous
solubility and hence poor bioavailability. In this work, attempts
were made to formulate new solid forms of Curcumin with several coformers,
mainly to enhance the dissolution rate of curcumin in aqueous medium.
Ibuprofen, succinic acid, paracetamol, carbamazepine, ethyl paraben,
glycine, tyrosine, N-acetyl d,l-tryptophan and biotin are the coformers investigated in this study.
Binary phase diagrams were constructed for each binary system which
helped in identifying the nature and the composition of the solid
phase. All binary systems except curcumin–ibuprofen exhibited
eutectic formation. The curcumin–ibuprofen system resulted
in a physical mixture. These solid phases were further characterized
through powder X-ray diffraction, differential scanning calorimetry,
Fourier transform infrared spectroscopy and Raman spectroscopy. Dissolution
studies conducted for eutectics showed enhanced dissolution rates
as compared to raw curcumin. The results obtained were compared with
the literature reports to present a consolidated account of research
being conducted to enhance aqueous solubility of curcumin by developing
new solid forms of curcumin such as eutectics, coamorphous solids,
and cocrystals. Further, attempts have been made to understand how
molecular geometry and intermolecular interactions influence the formation
of a specific solid form.
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Keywords
powder X-ray diffractionBinary Phase Diagramsliterature reportsturmeric plantBinary phase diagramsethyl parabenDissolution Studies Curcumincoamorphous solidsdissolution ratesRaman spectroscopyEnhanced Dissolution RatesCurcumin Eutecticsinteractions influencesuccinic acidscanning calorimetrypolyphenolic compoundeutectic formationanticancer propertiesCurcuma longadissolution ratecurcuminDissolution studies
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