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Copper Complexes of Thiosemicarbazone−Pyridylhydrazine (THYNIC) Hybrid Ligands: A New Versatile Potential Bifunctional Chelator for Copper Radiopharmaceuticals
journal contribution
posted on 2006-01-23, 00:00 authored by Andrew R. Cowley, Jonathan R. Dilworth, Paul S. Donnelly, Jonathan M. WhiteTwo new thiosemicarbazone−pyridylhydrazine (THYNIC) hybrid
ligands have been synthesized. Copper(II) and copper(I) complexes
of the ligands have been prepared and characterized by X-ray
crystallography. Cyclic voltammetry measurements show that the
copper(II) complexes undergo quasi-reversible reductions at
biologically accessible potentials. One of the ligands, bearing a
pendant carboxylate arm, has been conjugated to N-α-(tert-butoxycarbonyl)-l-lysine.