Copper- and Palladium-Catalyzed Cross-Coupling Reactions for the Synthesis of <i>N</i>‑Fused Benzo[4,5]imidazo[2,1‑<i>b</i>]thiazole Derivatives via Substituted <i>trans</i>-1,2-Diiodoalkenes, 1<i>H</i>‑Benzo[<i>d</i>]imidazole-2-thiols, and Halobenzenes

Two transition metal (Cu and Pd)-catalyzed C–S, C–N, and C–C bond cross-coupling reactions for the preparation of <i>N</i>-fused benzo­[4,5]­imidazo­[2,1-<i>b</i>]­thiazole derivatives were developed. A variety of 3-substituted and 2,3-disubstituted benzo­[4,5]­imidazo­[2,1-<i>b</i>]­thiazoles were efficiently and conveniently synthesized from the coupling reaction via <i>trans</i>-1,2-diiodoalkenes, 1<i>H</i>-benzo­[<i>d</i>]­imidazole-2-thiols, and halobenzenes in moderate to excellent yields.