Copper- and Palladium-Catalyzed Cross-Coupling Reactions for the Synthesis of N‑Fused Benzo[4,5]imidazo[2,1‑b]thiazole Derivatives via Substituted trans-1,2-Diiodoalkenes, 1H‑Benzo[d]imidazole-2-thiols, and Halobenzenes

Two transition metal (Cu and Pd)-catalyzed C–S, C–N, and C–C bond cross-coupling reactions for the preparation of N-fused benzo­[4,5]­imidazo­[2,1-b]­thiazole derivatives were developed. A variety of 3-substituted and 2,3-disubstituted benzo­[4,5]­imidazo­[2,1-b]­thiazoles were efficiently and conveniently synthesized from the coupling reaction via trans-1,2-diiodoalkenes, 1H-benzo­[d]­imidazole-2-thiols, and halobenzenes in moderate to excellent yields.