Copper- and Palladium-Catalyzed Cross-Coupling Reactions for the Synthesis of <i>N</i>‑Fused Benzo[4,5]imidazo[2,1‑<i>b</i>]thiazole Derivatives via Substituted <i>trans</i>-1,2-Diiodoalkenes, 1<i>H</i>‑Benzo[<i>d</i>]imidazole-2-thiols, and Halobenzenes
2017-03-16T00:00:00Z (GMT) by
Two transition metal (Cu and Pd)-catalyzed C–S, C–N, and C–C bond cross-coupling reactions for the preparation of <i>N</i>-fused benzo[4,5]imidazo[2,1-<i>b</i>]thiazole derivatives were developed. A variety of 3-substituted and 2,3-disubstituted benzo[4,5]imidazo[2,1-<i>b</i>]thiazoles were efficiently and conveniently synthesized from the coupling reaction via <i>trans</i>-1,2-diiodoalkenes, 1<i>H</i>-benzo[<i>d</i>]imidazole-2-thiols, and halobenzenes in moderate to excellent yields.
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