ol7b03299_si_001.pdf (2.86 MB)
Copper-Catalyzed Enantioselective Henry Reaction of β,γ‑Unsaturated α‑Ketoesters with Nitromethane in Water
journal contribution
posted on 2017-11-18, 17:30 authored by Yanan Li, Yekai Huang, Yang Gui, Jianan Sun, Jindong Li, Zhenggen Zha, Zhiyong WangA highly
enantioselective Henry reaction of β,γ-unsaturated
α-ketoesters with nitromethane in water by virtue of chiral
copper complexes has been developed. A series of unsaturated β-nitro-α-hydroxy
esters bearing tetrasubstituted carbon stereocenters were obtained
exclusively with high yields and excellent enantioselectivities. This
method could avoid tedious anaerobic anhydrous manipulation and reduce
the environmental pollution caused by organic solvents.