Convenient and efficient method for the synthesis of substituted quinolines via one-pot heteroannulation reaction of <i>o</i>-amino arylketones with α-methylene ketones under solvent-free conditions

2016-11-16T15:02:31Z (GMT) by G. Vanajatha V. Prabhakar Reddy
<p>A facile and practical approach to the synthesis of a wide range of functionalized quinolines was developed via a tandem heteroannulation reaction of <i>o</i>-aminoarylketones with diverse α-methylene ketones in high yields by using tetrabutylammonium peroxydisulfate as a versatile reagent (25 mol%) at ambient temperature under solvent-free conditions. This protocol was applied to the synthesis of drug-like molecules, which are key intermediates of alkaloid camptothecin.</p>