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Construction of RNA–Quantum Dot Chimera for Nanoscale Resistive Biomemory Application
journal contribution
posted on 2015-07-28, 00:00 authored by Taek Lee, Ajay Kumar Yagati, Fengmei Pi, Ashwani Sharma, Jeong-Woo Choi, Peixuan GuoRNA nanotechnology offers advantages to construct thermally and chemically stable nanoparticles with well-defined shape and structure. Here we report the development of an RNA–QD (quantum dot) chimera for resistive biomolecular memory application. Each QD holds two copies of the pRNA three-way junction (pRNA-3WJ) of the bacteriophage phi29 DNA packaging motor. The fixed quantity of two RNAs per QD was achieved by immobilizing the pRNA-3WJ with a Sephadex aptamer for resin binding. Two thiolated pRNA-3WJ serve as two feet of the chimera that stand on the gold plate. The RNA nanostructure served as both an insulator and a mediator to provide defined distance between the QD and gold. Immobilization of the chimera nanoparticle was confirmed with scanning tunneling microscopy. As revealed by scanning tunneling spectroscopy, the conjugated pRNA-3WJ–QD chimera exhibited an excellent electrical bistability signal for biomolecular memory function, demonstrating great potential for the development of resistive biomolecular memory and a nano-bio-inspired electronic device for information processing and computing.
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bacteriophage phi 29 DNA packaging motorSephadex aptamerresin bindingpRNAscanning tunneling spectroscopyquantum dotbiomolecular memorychimera nanoparticlebiomolecular memory functiongold platebistability signalNanoscale Resistive Biomemory ApplicationRNA nanotechnologyscanning tunneling microscopyinformation processingbiomolecular memory applicationQDRNA nanostructure
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