Congmujingnosides B-G, triterpene saponins from the stem of Aralia chinensis and their protective effects against H2O2-induced myocardial cell injury

Zhang, Wen; Zhu, Nailiang; Hu, Meigeng; Yu, Shichun; Sun, Zhonghao; Wu, Haifeng; Li, Pengfei; Yang, Junshan; Ma, Guoxu; Xu, Xudong

doi:10.6084/m9.figshare.5579923.v1

gnpl_a_1399384_sm6438.pdf (2.13 MB)

Congmujingnosides B-G, triterpene saponins from the stem of Aralia chinensis and their protective effects against H₂O₂-induced myocardial cell injury

journal contribution

posted on 2017-11-08, 13:17 authored by Wen Zhang, Nailiang Zhu, Meigeng Hu, Shichun Yu, Zhonghao Sun, Haifeng Wu, Pengfei Li, Junshan Yang, Guoxu Ma, Xudong Xu

Phytochemical investigation of the stem of Aralia chinensis yielded six new oleanane-type triterpene saponins named as congmujingnosides B-G (1–6). The new ones were elucidated on the basis of the chemical and spectroscopic analysis. Protective effects of compounds 1−6 were tested against H₂O₂-induced H9c2 cardiomyocyte injury, and the data showed that compounds 1 and 5 had significant cell-protective effects. No significant DPPH radical scavenging activity was observed for compounds 1−6.