ol402462h_si_001.pdf (4.38 MB)
Conformational Preferences of Zampanolide and Dactylolide
journal contribution
posted on 2013-10-18, 00:00 authored by Erik M. Larsen, Matthew R. Wilson, Jaroslav Zajicek, Richard E. TaylorThe solution conformation behavior of the macrolide core of microtubule-stabilizing agents (−)-zampanolide and (−)-dactylolide has been determined through a combination of high-field NMR experiments and computational modeling. Taken together, the results demonstrate that in solution both molecules exist as a mixture of three interconverting conformational families, one of which bears strong resemblance to zampanolide’s tubulin-bound conformation.