Conditional <i>Ssb1</i>-deleted mice are sensitive to IR.

<p>(A) Schematic diagram of the radiation challenge assay in <i>Ssb1</i> deleted mice. <i>Rosa26</i>-CreER<sup>T2</sup>: <i>Ssb1</i><sup>+/+</sup>, <i>Rosa26</i>-CreER<sup>T2</sup>: <i>Ssb1</i><sup>+/−</sup> and <i>Rosa26</i>-CreER<sup>T2</sup>: <i>Ssb1</i><sup>−/−</sup> mice were challenged with 8 Gy of total body irradiation (TBI). The acute lethal response of mice to TBI was evaluated over a 30-day observation period. (B) Kaplan-Meier survival analysis of irradiated mice. Kaplan-Meier survival curves compared by log-rank (Mantel-Cox) analysis showed significant difference between <i>Rosa26</i>-CreER<sup>T2</sup>: <i>Ssb1</i><sup>−/−</sup> mice and the other two groups (**<i>P</i>&lt;0.01), while no difference was found between <i>Rosa26</i>-CreER<sup>T2</sup>: <i>Ssb1<sup>+/+</sup></i> and <i>Rosa26</i>-CreER<sup>T2</sup>: <i>Ssb1<sup>+/−</sup></i> groups. (C) Representative images of Haematoxylin and eosin, Ki67 (cell proliferation) and ApopTag (cell death) staining on small intestine sections from mice at Day 5 post 8 Gy of TBI.</p>



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