The levels of HPV-16/-18 Abs were measured using serum samples from children (Children), unvaccinated healthy women (Not-vaccinated), and vaccinated healthy women (Vaccinated), as well as from patients diagnosed as having cervical intraepithelial neoplasia grade 1 or 2 (CIN 1/2), CIN 3, or cervical cancer. A and B. Comparison of anti-HPV-16/-18 Ab concentrations in the sera of each category. Asterisk (*) represents p < 0.001, one-way ANOVA. C–F. Change in serum HPV-16/-18 Ab concentration at the indicated times post vaccination with Cervarix (C and D) and Gardasil (E and F).