Comparison of experimental patterns of antigenicity, predicted antigenicity, and conformational dynamics, for FC27 (left) and 3D7 (right) MSP2.
2015-03-05T15:07:10Z (GMT) by
<p>A. Antigenicity profiles of MSP2 inferred from experimental immunisation of mice (black) and rabbits (red) are plotted against the sequence. Black bars (top) denote the location of epitopes of a panel of monoclonal antibodies to MSP2. B. Conformational flexibility of MSP2 as measured by the spectral density functions derived from the <sup>15</sup>N relaxation data. Spectral density functions are plotted at zero frequency (black line) and at the <sup>15</sup>N Larmor frequency (red line). C. Antigenicity of MSP2 as predicated using BepiPred [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119899#pone.0119899.ref060" target="_blank">60</a>] (red, right axis) and the method of Kolaskar and Tongaonkar [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119899#pone.0119899.ref061" target="_blank">61</a>] (black, left axis). The threshold for epitope prediction for both methods is denoted by the grey line.</p>
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