Fig 4.tif (769.21 kB)
Coexpression of ErbB2 and beta1 integrin in breast cancer.
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posted on 2017-03-17, 17:29 authored by Andrés Martín Toscani, Rocío G. Sampayo, Federico Martín Barabas, Federico Fuentes, Marina Simian, Federico Coluccio Leskow(A) Dot-plot of mRNA expression Z-Scores for breast cancer samples published by TCGA in 2015 [60] with PAM50 characterization (black dots) and HER2-positive tumors (red dots). (B) Pearson´s correlation coefficient (r), two-tailed P value (P) and number of samples (n) for different invasive ductal carcinomas subtypes. *r values regarded as significant correlation (alpha = 0.05).
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breast cancer cellsErbB 2 overexpressionErbB 2 membrane domainsextracellular matrix proteins shape membrane clusters distributionextracellular matrix proteinsDistinct ErbB 2 receptor populations differentiallyplasma membraneErbB 2beta 1 integrinErbB 2 formstyrosine kinase receptorsErbB 2 colocalizationbreast cancer cell models ErbB 2beta 1 integrin activityexpression levelsbreast cancer progression
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