ol7b03348_si_001.pdf (4.07 MB)

Click, Release, and Fluoresce: A Chemical Strategy for a Cascade Prodrug System for Codelivery of Carbon Monoxide, a Drug Payload, and a Fluorescent Reporter

Download (4.07 MB)
journal contribution
posted on 29.01.2018 by Ladie Kimberly C. De La Cruz, Stéphane L. Benoit, Zhixiang Pan, Bingchen Yu, Robert J. Maier, Xingyue Ji, Binghe Wang
A chemical strategy was developed wherein a single trigger sets in motion a three-reaction cascade leading to the release of more than one drug-component in sequence with the generation of a fluorescent side product for easy monitoring. As a proof of concept, codelivery of CO with the antibiotic metronidazole was demonstrated.