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Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: a systematic review and meta-analysis
journal contribution
posted on 2020-01-23, 14:29 authored by Adam Causer, Janis Shute, Michael Cummings, Anthony Shepherd, Mathieu Gruet, Joseph Costello, Stephen BaileyStephen Bailey, Martin Lindley, Clare Pearson, Gary Connett, Mark Allenby, Mary Carroll, Thomas Daniels, Zoe SaynorIntroduction: Oxidative stress may play an important role in the pathophysiology of cystic fibrosis (CF). This review aimed to quantify CF-related redox imbalances.
Methods: Systematic searches of the Medline, CINAHL, CENTRAL and PsycINFO databases were conducted. Mean content of blood biomarkers from people with clinically-stable CF and non-CF controls were used to calculate the standardized mean difference (SMD) and 95% confidence intervals (95% CI).
Results: Forty-nine studies were eligible for this review including a total of 1,792 people with CF and 1,675 controls. Meta-analysis revealed that protein carbonyls (SMD: 1.13, 95% CI: 0.48 to 1.77), total F2-isoprostane 8-iso-prostaglandin F2α (SMD: 0.64, 95% CI: 0.23 to 1.05) and malondialdehyde (SMD: 1.34, 95% CI: 0.30 to 2.39) were significantly higher, and vitamins A (SMD: -0.66, 95% CI -1.14 to -0.17) and E (SMD: -0.74, 95% CI: -1.28 to -0.20), β-carotene (SMD: -1.80, 95% CI: -2.92 to -0.67), lutein (SMD: -1.52, 95% CI: -1.83 to -1.20) and albumin (SMD: -0.98, 95% CI: -1.68 to -0.27) were significantly lower in the plasma or serum of people with CF versus controls.
Conclusions: This systematic review and meta-analysis found good evidence for reduced antioxidant capacity and elevated oxidative stress in people with clinically-stable CF.
Funding
University of Portsmouth
History
School
- Sport, Exercise and Health Sciences
Published in
Redox BiologyVolume
32Issue
May 2020Publisher
ElsevierVersion
- VoR (Version of Record)
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© The AuthorsPublisher statement
This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).Acceptance date
2020-01-16Publication date
2020-01-23Copyright date
2020ISSN
2213-2317Publisher version
Language
- en
Depositor
Dr Stephen Bailey. Deposit date: 20 January 2020Article number
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