Chromium(III) complexes of dimethyl diphenyldithiophosphates: Synthesis, characterization, and antibacterial studies

<p></p> <p>Dimethyl diphenyldithiophosphate complexes of Cr(III), [{(ArO)<sub>2</sub>PS<sub>2</sub>}<sub>3</sub>Cr] [Ar = 2,4-(CH<sub>3</sub>)<sub>2</sub>C<sub>6</sub>H<sub>3</sub> (<b>1</b>), 2,5-(CH<sub>3</sub>)<sub>2</sub>C<sub>6</sub>H<sub>3</sub> (<b>2</b>),3,4-(CH<sub>3</sub>)<sub>2</sub>C<sub>6</sub>H<sub>3</sub> (<b>3</b>), and 3,5-(CH<sub>3</sub>)<sub>2</sub>C<sub>6</sub>H<sub>3</sub> (<b>4</b>)], have been synthesized and structurally characterized by IR, heteronuclear NMR (<sup>1</sup>H, <sup>13</sup>C, and <sup>31</sup>P) spectroscopic and single crystal X-ray analyses. The crystal structure of complex <b>4</b> reveals mononuclear units with the Cr(III) centre chelated in bidentate fashion by six S atoms of the three diphenyldithiophosphate ligands to form octahedral geometry. The main core of the system comprised of four membered (CrS<sub>2</sub>P)<sub>3</sub> heteroatomic ring and Cr(III) center. The ligands and complexes were evaluated for their antibacterial potential against six bacterial strains (<i>K. pneumoniae, E.coli, P. aeruginosa, B. subtilis, S. aureus</i>, and <i>S. typhimurium</i>). The metal derivatives of diphenyldithiophosphate ligands were found to be more active against the bacterial strains as compared to the free ligands.</p>