jf8b01055_si_001.pdf (281 kB)
Chicory Roots for Prebiotics and Appetite Regulation: A Pilot Study in Mice
journal contribution
posted on 2018-06-06, 00:00 authored by Marion Fouré, Camille Dugardin, Benoît Foligné, Philippe Hance, Thierry Cadalen, Abigael Delcourt, Bernard Taminiau, Georges Daube, Rozenn Ravallec, Benoit Cudennec, Jean-Louis Hilbert, Anca Lucau-DanilaThe
objectives of this work are to address the prebiotic effects
of chicory (Cichorium intybus) together with its
possible role in appetite control. We compared nine chicory genotypes
in order to determine if variations in the content of metabolites
in the roasted roots would lead to modifications in release of satiety
hormones and in composition of gut microbiota. To this aim, a 5-week
dietary-intervention study was achieved using mice fed with distinct
chicory-based preparations. A 16S rRNA gene-based metagenetic analysis
of fecal microbiota was performed. In vitro gastrointestinal digestions
were performed in order to study the effect of chicory intestinal
digests on gut hormone regulation in enteroendocrine cells. Firmicutes/Bacteroidetes
ratio and gut bacterial groups, such as Alloprevotella, Blautia, Alistipes, and Oscillibacter, were found to be modulated by chicory. On
the other hand, CCK and GLP-1 satiety hormones were demonstrated to
be significantly increased by chicory in vitro.