1471-2199-8-1-4.jpg (57.71 kB)
Chicken ovalbumin upstream promoter transcription factor II regulates uncoupling protein 3 gene transcription in -3
figure
posted on 2011-12-31, 03:23 authored by Tobias Fromme, Kathrin Reichwald, Matthias Platzer, Xing-Sheng Li, Martin KlingensporCopyright information:
Taken from "Chicken ovalbumin upstream promoter transcription factor II regulates uncoupling protein 3 gene transcription in "
BMC Molecular Biology 2007;8():1-1.
Published online 4 Jan 2007
PMCID:PMC1779797.
fold change relative to basal -2244luc level). Coup-TFII coactivates the promoter in all combinations. It is especially effective together with MyoD, RXRα and p300. Coup-TFI does not activate reporter gene expression demonstrating a specific effect of Coup-TFII. () Identification of the region mediating Coup-TFII transctivation by analysis of deletion reporter gene constructs. Shown in the upper panel is the basal activity and induction by Coup-TFII of all constructs, in the lower panel the experiment was repeated on a background of MyoD, RXRα and p300 (note the different axis scaling). The shaded area highlights the region that is exclusively found on -2244luc and is responsible for the Coup-TFII effect in both setups.