lcar_a_1315123_sm4003.pdf (1.72 MB)
Chemoenzymatic synthesis of tumor-associated antigen N3 minor octasaccharide
journal contribution
posted on 2017-05-02, 13:53 authored by Zhipeng Han, Congcong Chen, Caicai Meng, Tian Gao, Peng Peng, Xi Chen, Fengshan Wang, Hongzhi CaoA highly efficient chemoenzymatic approach was developed for the preparative scale synthesis of complex tumor-associated antigen N3 minor octasaccharide. The success of this approach relies on the highly efficient one-pot multi-enzyme based sequential enzymatic elongation of a chemically synthesized branched tetrasaccharide core structure.