nl302178s_si_001.pdf (958.71 kB)
Chemically Functionalized Water-Soluble Single-Walled Carbon Nanotubes Modulate Morpho-Functional Characteristics of Astrocytes
journal contribution
posted on 2012-09-12, 00:00 authored by Manoj
K. Gottipati, Irina Kalinina, Elena Bekyarova, Robert C. Haddon, Vladimir ParpuraWe report the use of chemically functionalized water-soluble
single-walled
carbon nanotubes (ws-SWCNTs) for the modulation of morpho-functional
characteristics of astrocytes. When added to the culturing medium,
ws-SWCNTs were able to make astrocytes larger and stellate/mature,
changes associated with the increase in glial fibrillary acidic protein
immunoreactivity. Thus, ws-SWCNTs could have more beneficial effects
at the injury site than previously thought; by affecting astrocytes,
they could provide for a more comprehensive re-establishment of the
brain computational power.