Chemical constituents from the roots and stems of <i>Litsea cubeba</i>

<div><p></p><p>A new monoterpene and a new lignan, named litsecols A and B (<b>1</b> and <b>2</b>), respectively, together with nine known compounds (<b>3</b>–<b>11</b>), were isolated in a continuous investigation on the roots and stems of <i>Litsea cubeba</i>. Their structures were elucidated on the basis of extensive spectroscopic data analysis, and the absolute configuration of <b>1</b> was resolved by X-ray diffraction analysis. Compounds <b>2</b>–<b>5</b> and <b>7</b>–<b>9</b> showed significant inhibitory activity against nitric oxide (NO) production in lipopolysaccharide (LPS)-induced murine microglial (Bv-2) cell line. Compounds <b>10</b> and <b>11</b> exhibited significant neuroprotective effect against hydrogen peroxide-induced oxidative damage in rat adrenal pheochromocytoma (PC12) cell line.</p></div>