Chemical composition and <i>in vitro</i> antileishmanial and cytotoxic activities of the essential oils of <i>Ocotea dispersa</i> (Nees) Mez and <i>Ocotea odorifera</i> (Vell) Rohwer (Lauraceae)

<p>We investigate the chemical composition and the <i>in vitro</i> antileishmanial and cytotoxic activities of the essential oils extracted from the leaves of <i>Ocotea dispersa</i> (Nees) Mez (OD-EO) and <i>Ocotea odorifera</i> (Vell) Rohwer (OO-EO). On the basis of GC-FID and GC-MS, α-eudesmol (20.9%), valencene (10.2%), δ-elemene (9.3%) and isospathulenol (7.3%) are the major constituents of OD-EO, whereas safrole (36.3%), γ-cadinene (6.6%), camphor (6.5%) and α-copaene (6.0%) are the main constituents of OO-EO. Both OD-EO and OO-EO display significant activity against the promastigote forms of <i>Leishmania amazonensis</i>, with IC<sub>50</sub> values of 4.67 ± 0.95 and 11.67 ± 2.16 μg/mL, respectively. The 50% cytotoxic concentration (CC<sub>50</sub>) of OD-EO and OO-EO to mouse peritoneal macrophages is 26.77 ± 4.06 and 49.52 ± 1.04 μg/mL, respectively. This is the first report on the chemical composition of the essential oil extracted from the leaves of <i>O. dispersa</i>. Our results suggest that OD-EO and OO-EO are a promising source of new antileishmanial agents.</p>