pntd.0006305.g007.tif (3.92 MB)
Characterization of the rhesus macaque (Macaca mulatta) scrub typhus model: Susceptibility to intradermal challenge with the human pathogen Orientia tsutsugamushi Karp - Fig 7
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posted on 2018-03-09, 18:37 authored by Piyanate Sunyakumthorn, Suwit J. Somponpun, Rawiwan Im-erbsin, Tippawan Anantatat, Kemajittra Jenjaroen, Susanna J. Dunachie, Eric D. Lombardini, Robin L. Burke, Stuart D. Blacksell, James W. Jones, Carl J. Mason, Allen L. Richards, Nicholas P. J. Day, Daniel H. ParisLocalization of intracellular O. tsutsugamushi in antigen presenting cells (APCs) in macaque tissues, (A and E) Eschar: BR1-02, (B) Spleen: BR1-02, (C) Draining lymph node (D-LN): BR1-03, (D) Non-draining lymph node (ND-LN): BR1-05 after 28 day pi.O. tsutsugamushi is labeled in green, APCs are characterized by MHC class II receptor (HLADR) and shown in red. Panels A-D show O. tsutsugamushi organisms associated with APCs in eschar, spleen, draining and non-draining lymph nodes. Panel E shows orthogonal views of confocal Z-stack images. DAPI nuclear counterstain in blue. Scale bars: 10 μm.
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intradermal inoculationfuture vaccine candidatestyphus disease modelwell-characterized animal modelsnon-draining lymph nodestsutsugamushi Karp strainday 14 picell adhesion moleculestime course investigationsliver enzyme function10 6 murine LD 50pathogen Orientia tsutsugamushi Karp BackgroundNHPtyphus modelresponsestudy host immunityrhesus macaques
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