Celgosivir treatment changes the systemic immune response during acute dengue infection.

A) Scatter plot of cytokine concentration of patient plasma samples drawn at specific time points post admission were analyzed for 41 cytokines and chemokines using the Human cytokine panel 1. The standard for each analyte between 4–10000 pg/ml is presented as yellow dashes, quality control for each analyte is in blue filled circles, a healthy volunteer (JEC) sample is shown in black filled circles the patient samples (400 samples/analyte; 8 per patient x 50 patients) are shown as green crosses. B) Heat map of log2 fold changes of averaged analyte concentrations at specific time points against the pre-treatment concentrations for selected analytes showing qualitative shifts in the analyte concentrations. Treatment and control groups fold changes are shown in separate rows for each analyte to aid comparison. Fold changes are colored from over expression in red to under expression in green. A scale showing the value of the maximum and minimum log2 fold change is shown.