ppat.1006872.g004.tif (3.57 MB)

CatB deficiency alleviated while cystatin C deficiency aggravated the severity of CVB3-induced VMC.

figure

posted on 2018-01-23, 18:36 authored by Yaping Wang, Liangliang Jia, Jian Shen, Yidong Wang, Zurong Fu, Sheng-an Su, Zhejun Cai, Jian-an Wang, Meixiang Xiang

(A, B) Representative HE staining in hearts from mice of indicated intervention. Scale bar: 50μm. The HE staining showed the infiltration of inflammatory cells and pathologic score was significantly decreased in Ctsb^-/-+CVB3 group while increased in Cstc^-/-+CVB3 group on day 7 pi, compared with WT+CVB3 group. (C) The serum cTnI level was significantly lower in Ctsb^-/-+CVB3 group and higher in Cstc^-/-+CVB3 group than the WT+CVB3 group on day 7 pi. (D-F) The echocardiographic data showed that cardiac dysfunction caused by CVB3 infection was significantly alleviated in Ctsb^-/-+CVB3 group, though there was no statistical difference between the Cstc^-/-+CVB3 group and the WT+CVB3 group. (WT group: n = 10; WT+CVB3 group: n = 14; Ctsb^-/-+CVB3 group: n = 12; Cstc^-/-+CVB3 group: n = 11; ***P<0.001 vs. WT group; #P<0.05 vs. WT+CVB3 group; &P<0.05 vs. Ctsb^-/-+CVB3 group; &&P<0.01 vs. Ctsb^-/-+CVB3 group).