Canonical pathways associated with array peptides with significantly altered phosphorylation.

Significantly enriched canonical pathways were identified with a right-tailed Fisher’s Exact Test. The test calculates a P-value determining the probability that each canonical pathway associated with the dataset is due to chance alone. A P-value of <0.05 was set as threshold for statistical significance. The P-values were corrected for multiple testing using the Benjamini-Hochberg method for correcting the false discovery rate. The z-score indicates predicted activation state of the canonical pathway. Blue color or lighter shades of blue indicate a negative z-score and down-regulation of the pathway, and orange color or lighter shades of orange indicate a positive z-score and up-regulation of the pathway. Ratio denotes the number of significantly expressed genes compared with the total number of genes associated with the canonical pathway.