Fig 4.TIF (1.97 MB)
CaMKII is required for ES-induced p-CREB in DRGNs.
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posted on 2016-09-09, 18:07 authored by Xiaodong Yan, Juanfang Liu, Zhengxu Ye, Jinghui Huang, Fei He, Wei Xiao, Xueyu Hu, Zhuojing LuoExpression and quantification of p-CREB in cells treated with CaMKs inhibitors KN93 (A; F-value = 11.832), KN62 (B; F-value = 32.494), and STO609 (C; F-value = 18.096) (mean ± SD; n = 3). Histone was used as a loading control. DMSO was used as vehicle control. *P < 0.05 compared to ES-/DMSO group; #P < 0.05 compared to ES+/DMSO group; &P < 0.05 compared to ES-/STO609.
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brain-derived neurotrophic factorcalmodulin-dependent protein kinase IIBDNF transcriptionCaMKII-Mediated CREB Phosphorylationneurite outgrowthElectrical Stimulation Electrical stimulationinhibitors KN 93Neurite Outgrowth PromotedcAMP-response element binding proteinCaMKII β subunitES-triggered nerve regenerationDRGNInduced BDNF mRNA Transcriptionrat postnatal dorsal root ganglion neurons
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