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COX2 restricts A. phagocytophilum infection in vivo.

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posted on 2016-08-02, 04:30 authored by Xiaowei Wang, Dana K. Shaw, Holly L. Hammond, Fayyaz S. Sutterwala, Manira Rayamajhi, Kari Ann Shirey, Darren J. Perkins, Joseph V. Bonventre, Thangam S. Velayutham, Sean M. Evans, Kyle G. Rodino, Lauren VieBrock, Karen M. Scanlon, Nicholas H. Carbonetti, Jason A. Carlyon, Edward A. Miao, Jere W. McBride, Michail Kotsyfakis, Joao H. F. Pedra

A. phagocytophilum infection of WT (n = 20) and COX2 (ptgs2)-/- (n = 10) mice. Bacterial load in the (A) peripheral blood of infected mice at day 15. (B) IL-18, (C) PGE2, (D) PGD2 and (E) TBXA2 release in the serum of infected animals. (F-G) Splenomegaly for COX2 (ptgs2-/-) mice infected with A. phagocytophilum. (H) Splenic architecture depicting the red (RP) and the white (WP) pulp during A. phagocytophilum infection. One-way ANOVA-Tukey; Student t test; *P < 0.05. NS–not significant. (-) non-stimulated.

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    PLOS Pathogens

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    bacterium Anaplasma phagocytophilumEP 3 receptorProstaglandin E 2Mediated NLRC 4 Inflammasome Activation Rickettsial agentsPGE 2NLRC 4 inflammasome activationNLRC 4 inflammasomeEP 3 Receptor Axis Regulates Anaplasma phagocytophilumprostaglandin E synthaseCOXeicosanoid prostaglandin E 2RIPK2 cleaves arachidonic acidPGE 2 biosynthesisfacultative intracellular bacteriaILpattern recognition receptors

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