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CMA web interface and results of identification of the CM discriminating promoters of up-regulated genes from promoters of down-regulated genes upon TNF-alpha stimulation of primary human endothelial cells
figure
posted on 2011-12-31, 01:53 authored by T. Waleev, D. Shtokalo, T. Konovalova, N. Voss, E. Cheremushkin, P. Stegmaier, O. Kel-Margoulis, E. Wingender, A. KelCopyright information:
Taken from "Composite Module Analyst: identification of transcription factor binding site combinations using genetic algorithm"
Nucleic Acids Research 2006;34(Web Server issue):W541-W545.
Published online 14 Jul 2006
PMCID:PMC1538785.
© The Author 2006. Published by Oxford University Press. All rights reserved
() CMA web interface; () representation of the identified CM that consists of three single weight matrices and three pairs of matrices. The distance limits orientation of the sites in the pairs are schematically shown. () Two histograms of the fuzzy promoter score () in the promoters of up-regulated genes (red) and in down-regulated genes (blue); () representation of TF sites found in the windows that correspond to the maximal score of the match of the CM in the promoters. Marked are identified NF-AT/EGR2 site pairs (red) and IK3/IRF1 site pairs (blue).