ja401385v_si_001.pdf (3.31 MB)
Building Biologics by Chemical Synthesis: Practical Preparation of Di- and Triantennary N‑Linked Glycoconjugates
journal contribution
posted on 2013-03-27, 00:00 authored by Maciej
A. Walczak, Joji Hayashida, Samuel J. DanishefskyA unified
strategy for the syntheses of bi- and triantennary fully
sialylated N-glycans is described. The synthesis
capitalizes on a global glycosylation strategy that delivers the desired
undeca- and tetradecasaccharide in excellent yields. Finally, conjugation
of the glycan to PSMA oligopeptide is described.