id5b00060_si_001.pdf (70.08 kB)
Border Control in Hepatitis C Virus Infection: Inhibiting Viral Entry
journal contribution
posted on 2015-09-11, 00:00 authored by Cameron J. Schweitzer, T. Jake LiangA new era has begun in the treatment
of hepatitis C virus (HCV) infection with powerful yet expensive therapies.
New treatments are emerging that target the entry step of HCV and
could potentially block reinfection after liver transplant. These
treatments include antibodies, which target the virus or host receptors
required by HCV. Additionally, several new and previously approved
small-molecule compounds have been described that target unique aspects
of HCV entry. Overall, the blocking entry represents an attractive
strategy that could yield powerful combination therapies to combat
HCV.