mt9b00630_si_001.pdf (3.91 MB)
Biosafety and Biokinetics of Noble Metals: The Impact of Their Chemical Nature
journal contribution
posted on 2019-10-04, 19:18 authored by Domenico Cassano, Ana-Katrina Mapanao, Maria Summa, Ylea Vlamidis, Giulia Giannone, Melissa Santi, Elena Guzzolino, Letizia Pitto, Laura Poliseno, Rosalia Bertorelli, Valerio VolianiEffective
excretion of nanostructured noble metals is still one
of the most challenging bottlenecks for their employment in clinical
practice. Besides the persistence issue, the clinical translation
of inorganic nanomaterials is also affected by a bewildering lack
of investigations regarding their quantitative biokinetics. Here,
we have quantitatively correlated the chemical nature of the three
most interesting noble metals for biomedical applications to their
biosafety and biokinetics in, respectively, zebrafish and murine models.
Gold, silver, and platinum ultrasmall-in-nano architectures with comparable
size elicit, after intravenous administration, different excretion
pathways depending on their intrinsic metallic nature. Understanding
the in vivo fate of noble metal nanoparticles is
a significant breakthrough to unlock their clinical employment for
the establishment of treatments for neoplasms, infectious diseases,
and neurological disorders.