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Bioinspired from Salivary Acquired Pellicle: A Multifunctional Coating for Biominerals
journal contribution
posted on 2017-06-09, 00:00 authored by Xiao Yang, Fuhui Huang, Xinyuan Xu, Yanpeng Liu, Chunmei Ding, Kefeng Wang, Anran Guo, Wei Li, Jianshu LiManipulation
of the surface properties of biominerals is very important
for their biomedical applications. However, the straightforward preparation
of a multifunctional and stable coating on biominerals remains a challenge.
Herein we report a rapid and universal method for the preparation
of multifunctional coatings on various biominerals using a salivary
acquired pellicle (SAP) inspired dendrimer. The dendrimer has a highly
branched structure and an external surface modified with DDDEEKC peptide.
It mimics the adsorption function of statherin, which is one of the
main components of SAP, to endow the coating with a universal capability
for adhesion on various biominerals such as hydroxyapatite, tertiary
calcium phosphate, calcium carbonate, pearls, enamel, dentin, and
bone. The coating can be formed by a simple dip-coating method on
the surface of biominerals within 10 min, and is stable for more than
1 month. The coating can also provide a general platform for secondary
modifications. For example, we use pregrafting or postgrafting methods
to introduce functional molecules such as fluorescein isothiocyanate,
heptadecafluoroundecanoyl chloride, and collagen to the surface of
the coatings, thus these biomineral surfaces can be applied for different
applications such as for protein crystallization by forming superhydrophobic
surface, or promoting cell adhesion and proliferation by immobilizing
collagen.
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protein crystallizationBiominerals Manipulationadsorption functionfluorescein isothiocyanate10 minMultifunctional Coatingcalcium phosphate1 monthDDDEEKC peptidedip-coating methodcalcium carbonateSAPmultifunctional coatingsbiomineral surfacescell adhesionheptadecafluoroundecanoyl chloridepostgrafting methodssuperhydrophobic surfacesurface propertiesimmobilizing collagenuse pregrafting
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