Biochemical pathways and molecular targets involved in the mechanism of action of ozonide antimalarials in Plasmodium falciparum

2018-08-09T08:38:16Z (GMT) by CARLO GIANNANGELO
This thesis examined the mechanism of action of new medicines for malaria, known as ozonides. Many malaria deaths are caused by multi-drug resistant parasites that can escape the effect of current malaria medicines. This thesis identified that the parasite haemoglobin digestion pathway plays a central role in the mechanisms of action and resistance of ozonide antimalarials. This detailed mechanistic understanding will facilitate further development and clinical utilisation of ozonides by allowing rational selection of partner drugs and monitoring for resistance.