Bioactivity and chemical composition of the essential oil from the leaves of <i>Guatteria australis</i> A.St.-Hil

<div><p>Essential oil from the leaves of <i>Guatteria australis</i> was obtained by hydrodistillation, analyzed by Gas Chromatography coupled to Mass Spectromery (GC–MS) and their antiproliferative, antileishmanial, antibacterial, antifungal and antioxidant activities were also evaluated. Twenty-three compounds were identified among which germacrene B (50.66%), germacrene D (22.22%) and (<i>E</i>)-caryophyllene (8.99%) were the main compounds. The highest antiproliferative activity was observed against NCI-ADR/RES (TGI = 31.08 μg/ml) and HT-29 (TGI = 32.81 μg/ml) cell lines. It also showed good antileishmanial activity against <i>Leishmania infantum</i> (IC<sub>50</sub> = 30.71 μg/ml). On the other hand, the oil exhibited a small effect against <i>Staphylococcus aureus</i> ATCC 6538, <i>S. aureus</i> ATCC 14458 and <i>Escherichia coli</i> ATCC 10799 (MIC = 250 μg/ml), as well as small antioxidant activity (457 μmol TE/g) assessed through ORAC<sub>FL</sub> assay. These results represent the first report regarding chemical composition and bioactivity of <i>G. australis</i> essential oil.</p></div>