Fig 8.tif (837.91 kB)
Behavioral deficits correlate with decreasing PO2 in cortical grey matter.
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posted on 2016-12-01, 18:08 authored by Thomas W. Johnson, Ying Wu, Nabeela Nathoo, James A. Rogers, V. Wee Yong, Jeff F. Dunn(A) Behavior deficit scores are shown over the course of the disease. Deficits were seen by day 7. 10/16 mice had a score > 4 and 3/16 had a score > 10. One mouse was not included as it never showed symptoms. (B) Absolute PO2 values grouped by behavior score. PO2 values decrease as behavioral deficit increases (t-test with Bonferroni’s correction; mean ± SD, ** = p < 0.01).
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Gray Matter HypoxiaWMObjective Quantify oxygenationhypoxiaExperimental Autoimmune Encephalomyelitis Modelmouse EAE modelMethods C 57BL miceMultiple Sclerosis Background Multiple sclerosistime-matched controlsPO 2MSMOGcerebellar GMinflammation-induced mouse modelPO 2 sensorscerebellumSD36 days post-inductionmyelin oligodendrocyte glycoproteincortex
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