Basic Ionic Liquid [bmIm]OH–Mediated Gewald Reaction as Green Protocol for the Synthesis of 2-Aminothiophenes

Rao Kaki, Venkata; Rao Akkinepalli, Raghuram; Kishore Deb, Pran; Rao Pichika, Mallikarjuna

doi:10.6084/m9.figshare.1181985.v3

lsyc_a_951898_sm7240.pdf (1.1 MB)

Basic Ionic Liquid [bmIm]OH–Mediated Gewald Reaction as Green Protocol for the Synthesis of 2-Aminothiophenes

Version 3 2014-11-26, 05:48

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journal contribution

posted on 2014-11-26, 05:48 authored by Venkata Rao Kaki, Raghuram Rao Akkinepalli, Pran Kishore Deb, Mallikarjuna Rao Pichika

A simple, efficient, and environmental friendly procedure was developed based on the Gewald reaction for the synthesis of 2-aminothiophenes using a basic ionic liquid [bmIm]OH as both catalyst and solvent. Besides being a green protocol, the method offers advantages of successful synthesis of a variety of alkyl, aryl, alkoxy, and alkylamino-2-aminothiophenes in good yields.