B cell dynamics in SIV-infected rhesus macaques.

<p>(A) Representative dot plots depicting gating strategy and the expression of CD21 and CD27 in B cells (CD3<sup>−</sup>CD20<sup>+</sup>) derived from blood, LNs and spleen is showed. B cell subsets were defined as naive (CD21<sup>+</sup>CD27<sup>−</sup>), resting memory (CD21<sup>+</sup>CD27<sup>+</sup>), activated memory (CD21<sup>−</sup>CD27<sup>+</sup>) and tissue memory (CD21<sup>−</sup>CD27<sup>−</sup>) B cells. (B) Percentages and (C) cell numbers for each B cell subset are shown. Each dot represents an individual RM. Statistical analyses were performed using Mann Whitney test. *, p<0.05; **, p<0.01. At day>180, open circles represent fast progressor RMs PB023 and PB028; and full diamonds represent slow progressor RMs PB013 and PB044. Axillary and Inguinal LNs are represented separately by two distinct dots for each RMs at day>180.</p>