B cell dynamics in SIV-infected rhesus macaques.
(A) Representative dot plots depicting gating strategy and the expression of CD21 and CD27 in B cells (CD3−CD20+) derived from blood, LNs and spleen is showed. B cell subsets were defined as naive (CD21+CD27−), resting memory (CD21+CD27+), activated memory (CD21−CD27+) and tissue memory (CD21−CD27−) B cells. (B) Percentages and (C) cell numbers for each B cell subset are shown. Each dot represents an individual RM. Statistical analyses were performed using Mann Whitney test. *, p<0.05; **, p<0.01. At day>180, open circles represent fast progressor RMs PB023 and PB028; and full diamonds represent slow progressor RMs PB013 and PB044. Axillary and Inguinal LNs are represented separately by two distinct dots for each RMs at day>180.