ol990330s_si_001.pdf (154.65 kB)
Asymmetric Catalytic Friedel−Crafts Reaction of Silyl Enol Ethers with Fluoral: A Possible Mechanism of the Mukaiyama-Aldol Reactions
journal contribution
posted on 1999-11-11, 00:00 authored by Akihiro Ishii, Jun Kojima, Koichi MikamiThe catalytic asymmetric Friedel−Crafts reaction of silyl enol ethers with fluoral proceeds under Mukaiyama-aldol conditions to give silyl enol
ether products. The sequential diastereoselective reactions of the resultant silyl enol ethers with electrophiles provide highly enantiopure
functionalized organofluorine compounds of material and pharmaceutical interest.