Association of cytokine levels with foreskin T cell density.

IL-8 and MIG were measured in coronal sulcus swabs (n = 89) taken immediately prior to circumcision, and densities of T cell subsets were measured in foreskin tissue by flow cytometry and IHC. A-F: Correlation of IL-8 concentration with the following densities of T cell populations are displayed: (A) CD8+ T cells; (B) CD4+ T cells; (C) CCR5+ CD4 T cells; (D) Th17 cells; (E) Th1 cells; and (F) TNFα+ CD4 T cells. G: Median and range of total foreskin CD4 and CD8 T cell density stratified by detection of MIG and compared using Mann-Whitney U test. All data are log₁₀ transformed.