Association of ATRX with pericentric heterochromatin and the Y chromosome of neonatal mouse spermatogonia-1

Red) at pericentric heterochromatin (thin arrow), H3K9(green) remained associated with centromeric domains in the chromosomes of neonatal spermatogonia. Importantly, H3K9is also preferentially associated with one of the unmethylated chromosomes on each spread analyzed (bold arrow). In contrast, H3K4(green) remains associated with entire chromatids in the majority of chromosomes (thin arrow). However, one of the unmethylated chromosomes was consistently found to be completely devoid of H3K4(bold arrow). Notably, the chromatin remodeling protein ATRX (green) remains associated with pericentric heterochromatin and consistently marks a single unmethylated chromosome on each metaphase spread analyzed. Scale bar = 10 μm.

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Taken from "Association of ATRX with pericentric heterochromatin and the Y chromosome of neonatal mouse spermatogonia"

http://www.biomedcentral.com/1471-2199/9/29

BMC Molecular Biology 2008;9():29-29.

Published online 13 Mar 2008

PMCID:PMC2275742.