tgcl_a_1510992_sm3508.pdf (2.74 MB)
Assessment of amination reactions via nucleophilic aromatic substitution using conventional and eco-friendly energies
journal contribution
posted on 2018-08-25, 11:55 authored by Ricardo A. Luna-Mora, Ángeles Torres-Reyes, Oscar A. González-Cruz, Fernando Ortega-Jiménez, Hulme Ríos-Guerra, Jessica V. González-Carrillo, Francisco Barrera-Téllez, Javier Perez-Flores, José G. Penieres-CarrilloThe efficiency of conventional heating energy source compared with Infrared (IR), Ultrasound (US), Microwave and the simultaneous combination US–IR eco-friendly approaches for preparation of new N-(5-R1 -amino-2-nitrophenyl)acetamides and 5-R1-amino-2-nitroaniline by Nucleophilic Aromatic Substitution (SNAr) via addition–elimination reactions on the halogens F, Cl, Br, I, employing amines as nucleophiles were explored. Moreover, phenyldiazenyl derivatives in good yields by an oxidative one-pot SNAr-based amination reaction from an unusual oxidation of 2-phenylhydrazinyl derivatives in DMSO was prepared.