np300833y_si_001.pdf (865.74 kB)
Antioxidant and Anti-inflammatory Meroterpenoids from the Brown Alga Cystoseira usneoides
journal contribution
posted on 2013-04-26, 00:00 authored by Carolina de los Reyes, Hanaa Zbakh, Virginia Motilva, Eva ZubíaA chemical study of the alga Cystoseira usneoides has led to the isolation of six new
meroterpenoids, cystodiones
A–F (1–6), together with six
known related compounds (7–12). The
structures of the new metabolites have been established by spectroscopic
techniques. In antioxidant assays all of the tested meroterpenes,
and in particular cystodiones A (1) and B (2), 6-cis-amentadione-1′-methyl ether (7), and amentadione-1′-methyl ether (8), exhibited strong radical-scavenging activity. In anti-inflammatory
assays, usneoidone Z (11) and its corresponding 6E isomer (12) showed significant activity as
inhibitors of the production of the proinflammatory cytokine TNF-α
in LPS-stimulated THP-1 human macrophages.